Erdie C R, Wills J W
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130.
J Virol. 1990 Oct;64(10):5204-8. doi: 10.1128/JVI.64.10.5204-5208.1990.
Rous sarcoma virus is an example of a replication-competent retrovirus whose Gag protein is not modified with myristic acid. The purpose of the experiments described in this report was to determine whether the addition of this 14-carbon fatty acid would interfere with the replication of Rous sarcoma virus. We found that myristylated derivatives of the Rous sarcoma virus Gag protein are fully functional for particle formation in avian cells and that the addition of myristic acid has very little effect on infectivity.
劳氏肉瘤病毒是一种具有复制能力的逆转录病毒，其 gag 蛋白未被肉豆蔻酸修饰。本报告中所述实验的目的是确定添加这种 14 碳脂肪酸是否会干扰劳氏肉瘤病毒的复制。我们发现，劳氏肉瘤病毒 gag 蛋白的肉豆蔻酰化衍生物在禽类细胞中形成病毒颗粒时功能完全正常，并且添加肉豆蔻酸对感染性的影响很小。
