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烟曲霉分离株中唑类耐药性主要归因于 CYP51A 基因中的 TR/L98H 突变，这是 ARTEMIS 全球监测研究的结果。

Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.

机构信息

Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4465-8. doi: 10.1128/AAC.00185-11. Epub 2011 Jun 20.

DOI:10.1128/AAC.00185-11
PMID:21690285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165364/
Abstract

We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.

摘要

我们调查了 2008 年至 2009 年期间作为 ARTEMIS 全球监测研究的一部分收集的 497 株烟曲霉分离株，这些分离株的 MIC 值升高，对伊曲康唑、伏立康唑和泊沙康唑敏感。cyp51A 基因的测序显示，29 株对一种或多种三唑类药物 MIC 值升高的分离株，均来自中国，含有与耐欧洲烟曲霉分离株相关的 TR/L98H 突变。这是首次在欧洲以外地区发现 TR/L98H 突变。

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Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.烟曲霉分离株中唑类耐药性主要归因于 CYP51A 基因中的 TR/L98H 突变，这是 ARTEMIS 全球监测研究的结果。
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本文引用的文献

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Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.在法国血液恶性肿瘤患者接受治疗的队列中，烟曲霉对唑类药物的耐药率较低。
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Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Aspergillus species to the triazoles.利用流行病学截断值研究 9 年来 Aspergillus 属对三唑类药物敏感性的变化趋势。
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Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain.奥地利、丹麦和西班牙的唑类耐药烟曲霉和其他曲霉的环境研究。
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J Antimicrob Chemother. 2010 Oct;65(10):2116-8. doi: 10.1093/jac/dkq279. Epub 2010 Aug 20.
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Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document).CLSI 肉汤微量稀释法（M38-A2 文件）中三唑类药物和六种曲霉菌属的野生型 MIC 分布和流行病学折点值。
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Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.唑类药物治疗期间烟曲霉对唑类药物耐药性的发展与毒力变化有关。
PLoS One. 2010 Apr 9;5(4):e10080. doi: 10.1371/journal.pone.0010080.
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Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma.患者肺曲霉菌病中出现对伏立康唑和伊曲康唑的获得性耐药。
Med Mycol. 2010 Feb;48(1):197-200. doi: 10.3109/13693780902717018.
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Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?烟曲霉中的唑类抗性：环境中使用杀菌剂的副作用？
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Wild-type MIC distribution and epidemiological cutoff values for Aspergillus fumigatus and three triazoles as determined by the Clinical and Laboratory Standards Institute broth microdilution methods.根据临床和实验室标准协会的肉汤微量稀释方法，确定了烟曲霉野生型 MIC 分布和三种三唑类药物的流行病学截断值。
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