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应用基于微球的 Luminex 检测技术对大型全球烟曲霉种复合体进行特异性筛选。

Screening of a large global Aspergillus fumigatus species complex collection by using a species-specific microsphere-based Luminex assay.

机构信息

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Clin Microbiol. 2009 Dec;47(12):4171-2. doi: 10.1128/JCM.01415-09. Epub 2009 Sep 30.

DOI:10.1128/JCM.01415-09
PMID:19794043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2786642/
Abstract

A microsphere-based Luminex assay was developed and validated for rapid identification of Aspergillus fumigatus from the other species within the A. fumigatus species complex (section Fumigati). This molecular tool was then employed to screen 499 clinical A. fumigatus species complex isolates collected from multiple medical centers throughout the world with results demonstrating the exclusive presence of A. fumigatus.

摘要

开发并验证了一种基于微球的 Luminex 检测方法，用于快速鉴定烟曲霉与其同属种复合体（烟曲霉菌组）内的其他菌种。该分子工具随后用于筛查从世界各地多个医疗中心收集的 499 株临床烟曲霉种复合体分离株，结果表明仅存在烟曲霉。

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J Clin Microbiol. 2009 Oct;47(10):3138-41. doi: 10.1128/JCM.01070-09. Epub 2009 Aug 12.
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J Clin Microbiol. 2009 Apr;47(4):1096-100. doi: 10.1128/JCM.01899-08. Epub 2009 Feb 25.
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In vitro survey of triazole cross-resistance among more than 700 clinical isolates of Aspergillus species.700多株曲霉菌临床分离株的三唑类交叉耐药性体外研究。
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Molecular studies reveal frequent misidentification of Aspergillus fumigatus by morphotyping.分子研究表明，通过形态分型对烟曲霉进行鉴定时经常出现错误。
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