Rochette Luc, Tatou Etienne, Maupoil Véronique, Zeller Marianne, Cottin Yves, Jazayeri Sahed, Brenot Roger, Girard Claude, David Michel, Vergely Catherine
Laboratoire de Physiologie et Pharmacologie Cardiovasculaires Expérimentales, Facultés de Médecine et de Pharmacie, 7 Bd. Jeanne d’Arc, Dijon Cedex, France.
Cell Physiol Biochem. 2011;27(5):497-502. doi: 10.1159/000329951. Epub 2011 Jun 15.
Heart failure is characterized by a great number of metabolic and histological defects, however, previous studies did not provide strong evidence of a correlation between the antioxidant status of myocardial tissue itself and cardiac function. The goal of our study was to assess, in patients with heart failure consecutive to dilated cardiomyopathy (DCM), alterations in norepinephrine (NE), lipid peroxidation (malonedialdehyde: MDA) and iron levels in different parts of the myocardium and aorta, in relation to functional parameters. Biopsied heart samples were obtained from 12 DCM patients and from 4 brain-dead organ donors (Controls). The left ventricular ejection fraction (LVEF) was reduced to 19.1±2.6% in DCM. For all patients, the distribution of NE in the atria, ventricles and vessels was different, but NE content in control hearts was systematically higher than in cardiomyopathy patients. MDA levels tended to be higher in the different samples from the DCM group in comparison with the values obtained in the C group; the values were significantly decreased (p<0.05) in endocardium and the aortic samples. In the right atrium there was a significant correlation between NE content and LVEF and between MDA and iron concentrations. These findings could give further insights into the relationship between iron metabolism disturbances and the severity of cardiovascular diseases.
心力衰竭的特征是大量代谢和组织学缺陷，然而，先前的研究并未提供心肌组织自身抗氧化状态与心脏功能之间存在关联的有力证据。我们研究的目的是评估扩张型心肌病（DCM）所致心力衰竭患者心肌和主动脉不同部位去甲肾上腺素（NE）、脂质过氧化（丙二醛：MDA）和铁水平的变化及其与功能参数的关系。从12例DCM患者和4例脑死亡器官供体（对照组）获取心脏活检样本。DCM患者的左心室射血分数（LVEF）降至19.1±2.6%。对所有患者而言，NE在心房、心室和血管中的分布不同，但对照心脏中的NE含量系统性地高于心肌病患者。与C组相比，DCM组不同样本中的MDA水平往往更高；心内膜和主动脉样本中的MDA值显著降低（p<0.05）。在右心房，NE含量与LVEF之间以及MDA与铁浓度之间存在显著相关性。这些发现可能会进一步深入了解铁代谢紊乱与心血管疾病严重程度之间的关系。
