催产素可刺激成年神经发生，即使在应激和糖皮质激素升高的情况下也是如此。
Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids.
机构信息
Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA.
出版信息
Hippocampus. 2012 Apr;22(4):861-8. doi: 10.1002/hipo.20947. Epub 2011 Jun 20.
Abstract
Oxytocin has been linked to social behavior, including social recognition, pair bonding and parenting, but its potential role in promoting neuronal growth has not been investigated. We show here that oxytocin, but not vasopressin, stimulates both cell proliferation and adult neurogenesis in the hippocampus of rats. Oxytocin is also capable of stimulating adult neurogenesis in rats subjected to glucocorticoid administration or cold water swim stress. These findings suggest that oxytocin stimulates neuronal growth and may protect against the suppressive effects of stress hormones on hippocampal plasticity.
摘要
催产素与社会行为有关，包括社会识别、配对结合和育儿，但它在促进神经元生长中的潜在作用尚未得到研究。我们在这里表明，催产素而不是加压素刺激大鼠海马中的细胞增殖和成年神经发生。催产素还能够刺激接受糖皮质激素给药或冷水游泳应激的大鼠的成年神经发生。这些发现表明，催产素刺激神经元生长，并可能防止应激激素对海马可塑性的抑制作用。
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