Heuer J G, von Bartheld C S, Kinoshita Y, Evers P C, Bothwell M
Department of Physiology and Biophysics, School of Medicine, University of Washington, Seattle 98195.
Neuron. 1990 Sep;5(3):283-96. doi: 10.1016/0896-6273(90)90165-c.
Patterns of expression of transcripts encoding receptors for fibroblast growth factor and nerve growth factor (FGF-R and NGF-R) in the developing chick nervous system are compared using in situ hybridization histochemistry. FGF-R transcripts are expressed abundantly in the germinal neuroepithelial layer. Expression ceases as cells migrate into the mantle layer and returns during late maturation of neuronal populations, including cholinergic nuclei of the basal forebrain, brainstem reticular and motor nuclei, and cerebellar Purkinje and granule neurons. The pattern of NGF-R expression is generally reciprocal to that of FGF-R in the CNS and in some phases of development of the PNS. These results suggest that FGF and NGF may act sequentially rather than in concert during neuronal development.
利用原位杂交组织化学方法比较了发育中的鸡神经系统中编码成纤维细胞生长因子受体和神经生长因子受体（FGF-R和NGF-R）的转录本的表达模式。FGF-R转录本在生发神经上皮层中大量表达。随着细胞迁移到套层，表达停止，并在神经元群体的晚期成熟过程中恢复，包括基底前脑的胆碱能核、脑干网状核和运动核，以及小脑浦肯野细胞和颗粒神经元。在中枢神经系统和周围神经系统发育的某些阶段，NGF-R的表达模式通常与FGF-R相反。这些结果表明，在神经元发育过程中，FGF和NGF可能是相继发挥作用，而不是协同发挥作用。
