Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
PLoS One. 2011;6(6):e21125. doi: 10.1371/journal.pone.0021125. Epub 2011 Jun 17.
We develop a novel nanohybrid showing a strong antibacterial activity on all of the tested pathogens, including methicillin-resistant Staphylococcus auerus and silver-resistant E. coli. The nanohybrid consists of silver nanoparticles (AgNPs) supported on 1 nm-thick silicate platelets (NSPs). The AgNP/NSP nanohybrid enables to encapsulate bacteria and triggers death signals from the cell membrane. The geographic shape of the NSPs concentrates AgNPs but impedes their penetration into attached cells, mitigating the detrimental effect of silver ion deposition in applied tissues. Moreover, the tightly tethered AgNPs on NSP surface achieve a stronger biocidal effect than silver nitrate, but bypassing Ag(+) mechanism, on silver-resistant bacteria. This nanohybrid presents an effective and safe antimicrobial agent in a new perspective.
我们开发了一种新型纳米杂化材料，对所有测试的病原体都表现出很强的抗菌活性，包括耐甲氧西林金黄色葡萄球菌和耐银大肠杆菌。该纳米杂化材料由负载在 1nm 厚的硅酸盐片层（NSPs）上的银纳米颗粒（AgNPs）组成。AgNP/NSP 纳米杂化材料能够包裹细菌，并从细胞膜引发死亡信号。NSP 的地理形状集中了 AgNPs，但阻止了它们进入附着的细胞，减轻了银离子在应用组织中沉积的有害影响。此外，NSP 表面上紧密结合的 AgNPs 比硝酸银实现了更强的杀菌效果，而且绕过了耐银细菌的 Ag(+)机制。这种纳米杂化材料从新的视角呈现了一种有效且安全的抗菌剂。
