Key Laboratory of Major Diseases in Children, Ministry of Education & National Key Discipline of Pediatrics, Ministry of Education & Department of Hematology, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Beijing, China.
Leuk Res. 2012 Jan;36(1):67-71. doi: 10.1016/j.leukres.2011.05.023. Epub 2011 Jun 21.
The prognostic significance of caspase 8 associated protein 2 (CASP8AP2) in pediatric ALL is controversial. We determined a cut-off of CASP8AP2 expression in bone marrow samples of 39 newly diagnosed patients, and found a significantly poor bone marrow relapse-free survival (p=0.019) in low-expression group and verified it in another cohort of 106 patients (p=0.002). Furthermore, as an independent prognostic factor, CASP8AP2 expression was correlated to minimal residual disease (MRD), and incorporating it with MRD would help to identify patients at greater risk of bone marrow relapse. We also developed an algorithm comprised of clinical risk and CASP8AP2 expression, which could predict bone marrow relapse more accurately.
Caspase 8 相关蛋白 2（CASP8AP2）在儿科急性淋巴细胞白血病（ALL）中的预后意义存在争议。我们在 39 例新诊断患者的骨髓样本中确定了 CASP8AP2 表达的截断值，发现低表达组的骨髓无复发生存率显著降低（p=0.019），并在另一组 106 例患者中得到了验证（p=0.002）。此外，作为一个独立的预后因素，CASP8AP2 表达与微小残留病（MRD）相关，将其与 MRD 相结合有助于识别骨髓复发风险较高的患者。我们还开发了一种包含临床风险和 CASP8AP2 表达的算法，该算法可以更准确地预测骨髓复发。
