Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
Environ Int. 2012 Jul;42:124-31. doi: 10.1016/j.envint.2011.05.012. Epub 2011 Jun 22.
The objective of this study was to investigate the concentrations, seasonal variations, bioaccessibility, and associated human daily intake of polybrominated diphenyl ethers (PBDEs) in in- and out-house dust collected in Shanghai, China. The PBDE concentrations varied from 131.6 to 3,886.7 ng g(-1) (with an average of 948.2 ng g(-1)) in in-house dust and from 8.7 to 3,116.3 ng g(-1) (with an average of 290.8 ng g(-1)) in out-house dust during four seasons. The PBDE concentrations in the autumn were the lowest for both in- and out-house dust. Among the detected PBDEs, BDE209 was the predominant congener, accounting for more than 80% of the total PBDE amounts. The bioaccessibility of PBDEs, measured using a simulation system of human gastrointestinal tract, was determined as 14.2-66.4% depending on individual PBDE congeners and showed significant negative correlations with organic matter in dust. After corrected with the bioaccessibility of PBDEs, the human daily intake of PBDEs via dust ingestion was calculated to be 0.4-21.4 and 4.3-40.6 ng day(-1) for an average adult and child in Shanghai, respectively. The values were much lower than most estimates in the literature, in which the bioaccessibility of PBDEs were not taken into account, suggesting that the intake of PBDEs may have been overestimated.
本研究旨在调查中国上海室内和室外灰尘中多溴二苯醚 (PBDEs) 的浓度、季节性变化、生物可及性以及与人体每日摄入量的关系。室内灰尘中 PBDE 浓度范围为 131.6-3886.7ng/g（平均值为 948.2ng/g），室外灰尘中浓度范围为 8.7-3116.3ng/g（平均值为 290.8ng/g），四个季节浓度存在差异。室内和室外灰尘中 PBDE 浓度在秋季最低。在所检测到的 PBDE 中，BDE209 是主要的同系物，占总 PBDE 含量的 80%以上。采用人体胃肠道模拟系统测量了 PBDE 的生物可及性，结果表明，不同 PBDE 同系物的生物可及性在 14.2%-66.4%之间，且与灰尘中的有机物呈显著负相关。经 PBDE 生物可及性校正后，上海市成人和儿童通过灰尘摄入 PBDE 的每日摄入量分别为 0.4-21.4 和 4.3-40.6ng/天。与文献中大多数未考虑 PBDE 生物可及性的估计值相比，这些值要低得多，这表明 PBDE 的摄入量可能被高估了。
