Weglarz L, Drózdz M, Wardas M
Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Biomed Biochim Acta. 1990;49(4):289-91.
Murine fibroblasts cultured in vitro were treated with hydrazinophthalazine drugs inducing the lupus erythematosus-like syndrome. Collagenase enzyme activity in the growth medium was found to be increased 3-fold by hydralazine and 1.8-fold by binazine, as compared to the control cultures. The enhanced level of collagenolytic activity points to the metabolic changes in the connective tissue in response to hydrazinophtalazines.
体外培养的小鼠成纤维细胞用诱导红斑狼疮样综合征的肼屈嗪类药物处理。与对照培养物相比，发现生长培养基中的胶原酶活性被肼屈嗪提高了3倍，被联苯嗪提高了1.8倍。胶原olytic活性水平的提高表明结缔组织对肼屈嗪类药物有代谢变化。
