Olczyk K, Kucharz E J, Drózdz M
Department of Clinical Chemistry and Laboratory Diagnostics, Silesian School of Medicine, Katowice, Poland.
Acta Med Hung. 1988;45(2):161-9.
Serum antinuclear antibodies were induced in rats by treatment with hydralazine or todralazine, given in daily dose of 25 mg/kg of body wt. for 12 months. An increased activity of alpha-glucosidase, beta-glucosidase, beta-galactosidase, alpha-fucosidase, beta-xylosidase was found in heart muscle, liver, kidney and lung. Hydralazine produced a more significant increase in the enzyme activity than todralazine. The obtained results suggest drug-induced connective tissue damage, probably of an inflammatory type. The mechanism of this phenomenon and its relationship to immunological alterations remain unclear.
通过给予大鼠每日25mg/kg体重的肼屈嗪或托屈嗪，持续治疗12个月来诱导大鼠产生血清抗核抗体。在心肌、肝脏、肾脏和肺中发现α-葡萄糖苷酶、β-葡萄糖苷酶、β-半乳糖苷酶、α-岩藻糖苷酶、β-木糖苷酶的活性增加。与托屈嗪相比，肼屈嗪使酶活性增加更为显著。所得结果提示药物诱导的结缔组织损伤，可能为炎症类型。这种现象的机制及其与免疫改变的关系仍不清楚。
