Drózdz M, Kucharz E, Anasz Z, Piwowarczyk B
Acta Physiol Pol. 1979 Sep-Dec;30(5-6):639-47.
Haematological investigations of peripheral blood and bone marrow were performed in rabbits receiving hydrazinophthalazines (hydralazine or binazin) with or without simultaneous hyperimmunization by means of repeated injections of bovine albumin. It was found that long-term administration of hydralazine caused appearance of LE factor in the serum and LE cells in blood. Less evident changes were caused by Binazin administration. Hyperimmunization caused weaknening of the effects of hydralazinophthalazines. Haematological investigations demonstrated hypochromic anaemia.
对接受肼屈嗪类药物（肼苯哒嗪或联苯嗪）的兔子进行了外周血和骨髓的血液学检查，这些兔子同时或不同时通过重复注射牛白蛋白进行超免疫。结果发现，长期给予肼苯哒嗪会导致血清中出现LE因子和血液中出现LE细胞。给予联苯嗪引起的变化不太明显。超免疫会削弱肼屈嗪类药物的作用。血液学检查显示为低色素性贫血。
