Drózdz M, Weglarz L, Wardas M, Kula B
Department of Biochemistry and Chemistry, Medical University School of Silesia, Katowice, Poland.
Clin Physiol Biochem. 1989;7(2):97-100.
Fibroblast cultures exposed to the drugs inducing a collagen-like syndrome (hydralazine and binazine) displayed growth inhibition and decrease in cellular protein content in a dose-dependent manner compared with control cultures. This was accompanied by the inhibitory effect of the drugs on DNA synthesis. The changes in the basic biochemical parameters of fibroblasts testify to the toxicity of hydrazinophthalazines in the connective tissue.
与对照培养物相比，暴露于诱导胶原样综合征的药物（肼屈嗪和二嗪）的成纤维细胞培养物呈现出剂量依赖性的生长抑制和细胞蛋白质含量降低。这伴随着药物对DNA合成的抑制作用。成纤维细胞基本生化参数的变化证明了肼酞嗪类药物在结缔组织中的毒性。
