Department of Radiology, School of Medicine, University of Kocaeli, Kocaeli Uni. Tip Fak Radyoloji AD, 41380 Umuttepe Kocaeli, Turkey.
Eur Radiol. 2011 Nov;21(11):2255-60. doi: 10.1007/s00330-011-2180-9. Epub 2011 Jun 23.
We aimed to evaluate the performance of diffusion-weighted magnetic resonance imaging in differentiating malignant from benign mediastinal lesions.
Fifty-three mediastinal lesions were examined with T1- and T2-weighted (W) conventional images. Then, two diffusion-weighted images were obtained with b = 0 and 1000 s/mm² values and apparent diffusion coefficients (ADC) were calculated. The statistical significance of differences between measurements was tested using the Student-t test.
The mean ADC of malignant lesions was significantly lower than that of the benign masses (p < 0.001). The cut-off value of ≤ 1.39 × 10(-3) mm²/s indicated a malignant lesion with a sensitivity of 95% and specificity of 87%.
Diffusion-weighted imaging may be helpful in differentiating benign from malignant mediastinal masses.
本研究旨在评估扩散加权磁共振成像（DWI）在鉴别纵隔良恶性病变中的性能。
对 53 例纵隔病变进行 T1 加权和 T2 加权（W）常规成像检查。然后，采集 b 值分别为 0 和 1000 s/mm² 的两个 DWI 图像，并计算表观扩散系数（ADC）。采用 Student-t 检验比较测量值之间的差异。
恶性病变的平均 ADC 值明显低于良性肿块（p<0.001）。ADC 值≤1.39×10(-3) mm²/s 为截断值时，提示恶性病变的灵敏度为 95%，特异性为 87%。
DWI 有助于鉴别纵隔良恶性肿块。
