神经肽Y对去大脑大鼠α2-肾上腺素能受体介导的心血管反应的影响。
Effect of neuropeptide Y on alpha 2-adrenoceptor-mediated cardiovascular responses in the pithed rat.
作者信息
Vila E, Macrae I M
机构信息
Department de Farmacologia i Psiquiatria, Universitat Autonoma de Barcelona, Bellaterra, Spain.
出版信息
Br J Pharmacol. 1990 Aug;100(4):840-2. doi: 10.1111/j.1476-5381.1990.tb14101.x.
Abstract
- The effects of neuropeptide Y (NPY) on the cardiovascular responses induced by stimulation of pre and postjunctional alpha 2-adrenoceptors were studied in the pithed normotensive rat. 2. The increase in diastolic blood pressure induced by cumulative injection of xylazine (1-1000 micrograms kg-1, i.v.) were potentiated by NPY (5 micrograms kg-1) but not affected by a lower dose (0.75 micrograms kg-1) of this peptide. 3. Xylazine (1-100 micrograms kg-1) inhibited in a dose-dependent manner the tachycardia induced by continuous electrical stimulation (0.2 Hz, 2 ms, 60 V) of the spinal cord (C7-Thl). 4. NPY (5 micrograms kg-1 but not 0.75 micrograms kg-1) enhanced the inhibitory effect of xylazine on the tachycardia induced by electrical stimulation without having any direct effect on heart rate. 5. These results suggest that there may be a positive interaction between NPY receptors, postjunctional alpha 2-adrenoceptors and between NPY receptors and postjunctional alpha 2-adrenoceptors in the cardiovascular system of the rat.
摘要
- 在脊髓麻醉的正常血压大鼠中，研究了神经肽Y（NPY）对刺激节前和节后α2 -肾上腺素能受体所诱导的心血管反应的影响。2. 静脉内累积注射赛拉嗪（1 - 1000微克/千克）所诱导的舒张压升高，被NPY（5微克/千克）增强，但不受该肽较低剂量（0.75微克/千克）的影响。3. 赛拉嗪（1 - 100微克/千克）以剂量依赖性方式抑制由脊髓（C7 - Th1）连续电刺激（0.2赫兹，2毫秒，60伏）所诱导的心动过速。4. NPY（5微克/千克而非0.75微克/千克）增强了赛拉嗪对电刺激诱导的心动过速的抑制作用，而对心率无任何直接影响。5. 这些结果表明，在大鼠心血管系统中，NPY受体、节后α2 -肾上腺素能受体之间以及NPY受体与节后α2 -肾上腺素能受体之间可能存在正向相互作用。
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本文引用的文献
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alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.α2肾上腺素能受体：分类、定位、作用机制及药物作用靶点
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