Department of Public Health, Environmental Health Sciences Division, School of Public Health an Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Regul Toxicol Pharmacol. 2011 Oct;61(1):73-81. doi: 10.1016/j.yrtph.2011.06.003. Epub 2011 Jun 15.
In 2005 we published an assessment of dose responses that satisfied a priori evaluative criteria for inclusion within the relational retrieval hormesis database (Calabrese and Blain, 2005). The database included information on study characteristics (e.g., biological model, gender, age and other relevant aspects, number of doses, dose distribution/range, quantitative features of the dose response, temporal features/repeat measures, and physical/chemical properties of the agents). The 2005 article covered information for about 5000 dose responses; the present article has been expanded to cover approximately 9000 dose responses. This assessment extends and strengthens the conclusion of the 2005 paper that the hormesis concept is broadly generalizable, being independent of biological model, endpoint measured and chemical class/physical agent. It also confirmed the definable quantitative features of hormetic dose responses in which the strong majority of dose responses display maximum stimulation less than twice that of the control group and a stimulatory width that is within approximately 10-20-fold of the estimated toxicological or pharmacological threshold. The remarkable consistency of the quantitative features of the hormetic dose response suggests that hormesis may provide an estimate of biological plasticity that is broadly generalized across plant, microbial and animal (invertebrate and vertebrate) models.
2005 年，我们发表了一篇关于剂量反应的评估，该评估满足了纳入关系检索激效数据库（Calabrese 和 Blain，2005）的先验评估标准。该数据库包含了研究特征的信息（例如，生物模型、性别、年龄和其他相关方面、剂量数、剂量分布/范围、剂量反应的定量特征、时间特征/重复测量以及试剂的物理/化学性质）。2005 年的文章涵盖了大约 5000 个剂量反应的信息；本文已扩展到涵盖大约 9000 个剂量反应。这项评估扩展并加强了 2005 年论文的结论，即激效概念具有广泛的通用性，不受生物模型、测量终点和化学类别/物理试剂的影响。它还证实了激效剂量反应的可定义定量特征，其中绝大多数剂量反应显示的最大刺激作用小于对照组的两倍，且刺激范围在估计的毒理学或药理学阈值的 10-20 倍左右。激效剂量反应的定量特征的显著一致性表明，激效可能提供了一种广泛适用于植物、微生物和动物（无脊椎动物和脊椎动物）模型的生物可塑性的估计。
