Anaesthesia, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Chelsea and Westminster Hospital, Imperial College School of Medicine, 369 Fulham Road, London SW10 9NH, UK.
Neuroscience. 2011 Sep 8;190:194-9. doi: 10.1016/j.neuroscience.2011.05.073. Epub 2011 Jun 12.
Peripheral orthopaedic surgery induces a profound inflammatory response. This includes a substantial increase in cytokines and, especially, in the level of interleukin (IL)-1β in the hippocampus, which has been shown to impair hippocampal-dependent memory in mice. We have employed two tests of contextual remote memory to demonstrate that the inflammatory response to surgical insult in mice also results in impairment of remote memory associated with prefrontal cortex (PFC). We have also found that, under the conditions presented in the social interaction test, peripheral orthopaedic surgery does not increase anxiety-like behaviour in our animal model. Although such surgery induces an increase in the level of IL-1β in the hippocampus, it fails to do so in the PFC. Peripheral orthopaedic surgery also results in a reduction in the level of hippocampal brain-derived neurotrophic factor (BDNF) and this may contribute, in part, to the memory impairment found after such surgery. Our data suggest that a reduction in the level of hippocampal BDNF and an increase in the level of hippocampal IL-1β following surgery may affect the transference of fear memory in the mouse brain.
外周骨科手术会引起强烈的炎症反应。这包括细胞因子的大量增加，特别是白细胞介素 (IL)-1β 在海马体中的水平升高，这已被证明会损害小鼠的海马体依赖记忆。我们采用了两种情境性远程记忆测试来证明，小鼠手术引起的炎症反应也会导致与前额叶皮层（PFC）相关的远程记忆受损。我们还发现，在社交互动测试中呈现的条件下，外周骨科手术不会增加我们动物模型中的焦虑样行为。尽管这种手术会增加海马体中 IL-1β 的水平，但在 PFC 中却不会增加。外周骨科手术还会导致海马体脑源性神经营养因子 (BDNF) 的水平降低，这可能部分导致手术后出现的记忆障碍。我们的数据表明，手术后海马体 BDNF 水平降低和海马体 IL-1β 水平升高可能会影响小鼠大脑中恐惧记忆的转移。
