David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science. 2011 Jun 24;332(6037):1554-7. doi: 10.1126/science.1204349.
Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage.
真核生物会衰老，但有害的与年龄相关的特征不会传递给后代。生命跨度如何从一代重置到下一代尚不清楚。我们表明，在出芽酵母中，寿命的重置发生在配子发生期间。来自衰老细胞的配子（孢子）与来自年轻细胞的配子具有相同的复制潜力。在成熟配子中不再检测到与年龄相关的损伤。此外，短暂诱导对于配子发生后期阶段至关重要的转录因子可延长衰老细胞的复制寿命。我们的结果表明，配子形成通过消除与年龄相关的细胞损伤而带来恢复活力。
