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The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis.ESCRT-III 复合物对于核孔复合体的隔离和调控芽殖酵母减数分裂中配子的复制寿命是必需的。
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本文引用的文献

1
Gametogenesis eliminates age-induced cellular damage and resets life span in yeast.配子发生消除了年龄引起的细胞损伤，并重置了酵母的寿命。
Science. 2011 Jun 24;332(6037):1554-7. doi: 10.1126/science.1204349.
2
Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains.核周 cohibin 复合物通过在不同沉默染色质域的作用维持复制寿命。
Dev Cell. 2011 Jun 14;20(6):867-79. doi: 10.1016/j.devcel.2011.05.014.
3
Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae.复制年龄诱导酿酒酵母核糖体 RNA 基因簇中的有丝分裂重组。
PLoS Genet. 2011 Mar;7(3):e1002015. doi: 10.1371/journal.pgen.1002015. Epub 2011 Mar 17.
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Mitochondria removal by autophagy.自噬作用清除线粒体。
Autophagy. 2011 Mar;7(3):297-300. doi: 10.4161/auto.7.3.14502.
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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.端粒酶重新激活可逆转端粒酶缺陷型老年小鼠的组织退化。
Nature. 2011 Jan 6;469(7328):102-6. doi: 10.1038/nature09603. Epub 2010 Nov 28.
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Carbonylated proteins are eliminated during reproduction in C. elegans.在 C. elegans 的繁殖过程中，羰基化蛋白被清除。
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7
Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis.系统筛选揭示了组蛋白 H3 和 H4 在配子发生过程中的新功能动态。
Genes Dev. 2010 Aug 15;24(16):1772-86. doi: 10.1101/gad.1954910.
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p53 Research: the past thirty years and the next thirty years.p53 研究：过去三十年和未来三十年。
Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000893. doi: 10.1101/cshperspect.a000893. Epub 2010 May 12.
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Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation in Saccharomyces cerevisiae.酵母细胞减数分裂过程中组蛋白 H4 丝氨酸 1 磷酸化的全基因组图谱。
Nucleic Acids Res. 2010 Aug;38(14):4599-606. doi: 10.1093/nar/gkq218. Epub 2010 Apr 7.
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The polarisome is required for segregation and retrograde transport of protein aggregates.极性体对于蛋白聚集体的分离和逆行运输是必需的。
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配子形成可重置酵母中的衰老时钟。

Gamete formation resets the aging clock in yeast.

作者信息

Ünal E, Amon A

机构信息

David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 2011;76:73-80. doi: 10.1101/sqb.2011.76.011379. Epub 2011 Sep 2.

DOI:10.1101/sqb.2011.76.011379
PMID:21890640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3912942/
Abstract

Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.

摘要

配子发生是一个生殖细胞分化为单倍体配子的过程。我们发现，在出芽酵母中，复制性衰老的细胞在配子发生过程中消除了年龄诱导的细胞损伤。重要的是，衰老细胞的配子与年轻细胞产生的配子具有相同的复制潜力，这表明在配子发生过程中寿命会重置。在这里，我们探讨了导致配子发生诱导的年轻化的潜在机制，并讨论了高等真核生物中类似的假定机制。