配子形成可重置酵母中的衰老时钟。
Gamete formation resets the aging clock in yeast.
作者信息
Ünal E, Amon A
机构信息
David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
出版信息
Cold Spring Harb Symp Quant Biol. 2011;76:73-80. doi: 10.1101/sqb.2011.76.011379. Epub 2011 Sep 2.
Abstract
Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
摘要
配子发生是一个生殖细胞分化为单倍体配子的过程。我们发现，在出芽酵母中，复制性衰老的细胞在配子发生过程中消除了年龄诱导的细胞损伤。重要的是，衰老细胞的配子与年轻细胞产生的配子具有相同的复制潜力，这表明在配子发生过程中寿命会重置。在这里，我们探讨了导致配子发生诱导的年轻化的潜在机制，并讨论了高等真核生物中类似的假定机制。
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