Institute for Collaborative Biotechnologies, University of California, Santa Barbara, California, USA.
J Appl Physiol (1985). 2011 Sep;111(3):938-45. doi: 10.1152/japplphysiol.00519.2010. Epub 2011 Jun 23.
Heat stroke (HS) is a serious civilian and military health issue. Due to the limited amount of experimental data available in humans, this study was conducted on a mouse mathematical model fitted on experimental data collected from mice under HS conditions, with the assumption there is good agreement among mammals. Core temperature (T(c)) recovery responses in a mouse model consist of hypothermia and delayed fever during 24 h of recovery that represent potential biomarkers of HS severity. The objective of this study was to develop a simulation model of mouse T(c) responses and identify optimal treatment windows for HS recovery using a three-dimensional predictive heat transfer simulation model. Several bioenergetic simulation variables, including nonlinear metabolic heat production (W/m³), temperature-dependent convective heat transfer through blood mass perfusion (W/m³), and activity-related changes in circadian T(c) were used for model simulation. The simulation results predicted the experimental data with few disparities. Using this simulation model, we tested a series of ambient temperature treatment strategies to minimize hypothermia and delayed fever to accelerate HS recovery. Using a genetic algorithm, we identified eight time segments (ambient temperature = 27, 30, 31, 29, 28, 28, 27, 26°C) of 110 min total duration that optimized HS recovery in our model simulation.
热射病（HS）是一个严重的民用和军事健康问题。由于人类可获得的实验数据有限，本研究在一个拟合了在 HS 条件下收集的实验数据的小鼠数学模型上进行，假设哺乳动物之间有很好的一致性。在小鼠模型中，核心温度（T(c)）恢复反应包括在 24 小时恢复期间的体温过低和延迟发热，这代表了 HS 严重程度的潜在生物标志物。本研究的目的是使用三维预测传热模拟模型开发一种模拟小鼠 T(c)反应的模型，并确定 HS 恢复的最佳治疗窗口。几个生物能量学模拟变量，包括非线性代谢产热（W/m³）、随温度变化的血液质量灌注的对流热传递（W/m³）和与活动相关的昼夜节律 T(c)变化，用于模型模拟。模拟结果与实验数据有一些差异。使用这种模拟模型，我们测试了一系列环境温度治疗策略，以最小化体温过低和延迟发热，从而加速 HS 恢复。使用遗传算法，我们确定了八个时间段（环境温度=27、30、31、29、28、28、27、26°C），总持续时间为 110 分钟，在我们的模型模拟中优化了 HS 的恢复。
