Department of Materials Science and Engineering, Institute for Nanobiotechnology, Johns Hopkins Center of Cancer Nanotechnology Excellence, Johns Hopkins Physical Sciences in Oncology Center, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Nat Rev Cancer. 2011 Jun 24;11(7):512-22. doi: 10.1038/nrc3080.
Metastasis is a complex, multistep process responsible for >90% of cancer-related deaths. In addition to genetic and external environmental factors, the physical interactions of cancer cells with their microenvironment, as well as their modulation by mechanical forces, are key determinants of the metastatic process. We reconstruct the metastatic process and describe the importance of key physical and mechanical processes at each step of the cascade. The emerging insight into these physical interactions may help to solve some long-standing questions in disease progression and may lead to new approaches to developing cancer diagnostics and therapies.
转移是一个复杂的多步骤过程，是导致超过 90%癌症相关死亡的原因。除了遗传和外部环境因素外，癌细胞与其微环境的物理相互作用，以及它们受到机械力的调节，是转移过程的关键决定因素。我们重建了转移过程，并描述了级联过程中每一步的关键物理和机械过程的重要性。对这些物理相互作用的新认识可能有助于解决疾病进展中的一些长期存在的问题，并可能导致开发癌症诊断和治疗方法的新方法。
