用人冠状病毒229E对猫进行实验性接种，随后用猫传染性腹膜炎病毒进行攻毒。
Experimental inoculation of cats with human coronavirus 229E and subsequent challenge with feline infectious peritonitis virus.
作者信息
Barlough J E, Johnson-Lussenburg C M, Stoddart C A, Jacobson R H, Scott F W
出版信息
Can J Comp Med. 1985 Jul;49(3):303-7.
Abstract
Minimal-disease cats exposed to live human coronavirus 229E developed homologous antibody responses that suggested little or no replication of the virus in inoculated animals. Oronasal and subcutaneous inoculation of coronavirus 229E did not elicit an antibody response by heterologous (transmissible gastroenteritis virus, canine coronavirus) neutralization or by heterologous (transmissible gastroenteritis virus) kinetics-based enzyme-linked immunosorbent assay. No clinical signs attributable to coronavirus 229E were seen in inoculated cats. Although the number of animals in each of the five experimental groups was small (n = 2), antibodies produced in response to the virus did not appear to sensitize cats to subsequent feline infectious peritonitis virus challenge, but neither did they cross-protect cats against the challenge dose.
摘要
暴露于活的人冠状病毒229E的微小病变猫产生了同源抗体反应，这表明该病毒在接种动物体内几乎没有复制或没有复制。经口鼻和皮下接种冠状病毒229E，通过异源（传染性胃肠炎病毒、犬冠状病毒）中和或基于异源（传染性胃肠炎病毒）动力学的酶联免疫吸附试验均未引发抗体反应。在接种的猫中未观察到可归因于冠状病毒229E的临床症状。尽管五个实验组中的每组动物数量较少（n = 2），但针对该病毒产生的抗体似乎并未使猫对随后的猫传染性腹膜炎病毒攻击敏感，也未对猫起到交叉保护作用以抵御攻击剂量。
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