经鼻给予干扰素对志愿者实验性呼吸道冠状病毒感染的防护作用
Intranasal interferon as protection against experimental respiratory coronavirus infection in volunteers.
作者信息
Higgins P G, Phillpotts R J, Scott G M, Wallace J, Bernhardt L L, Tyrrell D A
出版信息
Antimicrob Agents Chemother. 1983 Nov;24(5):713-5. doi: 10.1128/AAC.24.5.713.
Abstract
In a double-blind, placebo-controlled study, self-administered intranasal human interferon alpha A produced by recombinant DNA technology was given both before and after virus challenge with a respiratory coronavirus. The incidence of colds, the severity of symptoms and signs, and virus replication were all reduced in subjects receiving interferon as compared with those given placebo.
摘要
在一项双盲、安慰剂对照研究中，在呼吸道冠状病毒病毒攻击前后，均给予通过重组DNA技术生产的自行鼻内注射人干扰素αA。与给予安慰剂的受试者相比，接受干扰素的受试者感冒发病率、症状和体征的严重程度以及病毒复制均有所降低。
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