Chen Y T, Zheng R L, Jia Z J, Ju Y
Department of Biology, Lanzhou University, Gansu Province, China.
Free Radic Biol Med. 1990;9(1):19-21. doi: 10.1016/0891-5849(90)90045-k.
The superoxide anions scavenging activity and antioxidation of seven flavonoids--quercetin, rutin, morin, acacetin, hispidulin, hesperidin, and naringin--were studied. The superoxide anions were generated in a phenazin methosulphate-NADH system and were assayed by reduction of nitroblue tetrazolium. The scavenging activity ranked: rutin was the strongest, and quercetin and naringin the second, while morin and hispidulin were very weak. The concentration values yielding 50% inhibition of lipid peroxidation in mouse liver homogenate were in order of 10(-6) M for quercetin, rutin, and morin; and of 10(-5) M for acacetin and hispidulin, while naringin and hesperidin had no antioxidative action. In comparison with the antioxidative and scavenging activities of flavonoids, there are no correlations.
研究了七种黄酮类化合物——槲皮素、芦丁、桑色素、刺槐素、圣草素、橙皮苷和柚皮苷的超氧阴离子清除活性和抗氧化作用。超氧阴离子在硫酸吩嗪-NADH系统中产生，并通过硝基蓝四唑的还原进行测定。清除活性排序为：芦丁最强，槲皮素和柚皮苷次之，而桑色素和圣草素非常弱。在小鼠肝脏匀浆中产生50%脂质过氧化抑制作用的浓度值，槲皮素、芦丁和桑色素为10(-6)M；刺槐素和圣草素为10(-5)M，而柚皮苷和橙皮苷没有抗氧化作用。与黄酮类化合物的抗氧化和清除活性相比，不存在相关性。
