Arya S C, Pathak V P, Ashraf S J
King Fahad Central Hospital, Gizan, Saudi Arabia.
Infection. 1990 Jul-Aug;18(4):215-8. doi: 10.1007/BF01643389.
Four cases of type 2 hepatitis B virus (HBV-2) infection were demonstrated in the Gizan area of Saudi Arabia during the hepatitis B marker ELISA screening of the 152 native pregnant females, 42 cases of primary hepatocellular carcinoma, 19 cases with an epithelial but non-hepatic malignancy, 16 with a non-epithelial and non-hepatic malignancy and eight with chronic hepatitis. HBV-2 infection diagnosis was based on HBsAg positivity without anti-HBc, anti-HBs and HBeAg in one pregnant female and one patient each with a primary hepatocellular carcinoma, lymphocytic lymphoma and metastatic adenocarcinoma. During neutralisation of HBsAg ELISA reactivity, the respective reduction in absorbance values in sera from the pregnant female and the patient with primary hepatocellular carcinoma were 21% and 76% respectively. HBV-2 specific gene probes would be needed to define its role in pathogenesis of malignant neoplasms and chronic hepatitis. Incorporation of pre-S2 sequences in future hepatitis B vaccines is likely to protect against both, HBV-2 and conventional hepatitis B (HBV-1) exposures.
在沙特阿拉伯吉赞地区对152名本地孕妇、42例原发性肝细胞癌患者、19例上皮性非肝恶性肿瘤患者、16例非上皮性非肝恶性肿瘤患者和8例慢性肝炎患者进行乙肝标志物ELISA筛查期间，发现了4例2型乙肝病毒（HBV-2）感染病例。HBV-2感染的诊断依据是，1名孕妇以及分别患有原发性肝细胞癌、淋巴细胞淋巴瘤和转移性腺癌的1名患者的HBsAg呈阳性，而抗-HBc、抗-HBs和HBeAg呈阴性。在中和HBsAg ELISA反应性过程中，孕妇和原发性肝细胞癌患者血清中吸光度值的相应降低分别为21%和76%。需要HBV-2特异性基因探针来确定其在恶性肿瘤和慢性肝炎发病机制中的作用。未来的乙肝疫苗中纳入前S2序列可能会预防HBV-2和传统乙肝（HBV-1）感染。
