人乙肝表面抗原阳性反应并非由乙肝病毒所致。
HBsAG positive reactivity in man not due to hepatitis B virus.
作者信息
Coursaget P, Yvonnet B, Bourdil C, Mevelec M N, Adamowicz P, Barrès J L, Chotard J, N'Doye R, Diop Mar I, Chiron J P
机构信息
Institut de Virologie de Tours, Faculté de Pharmacie, Tours, France.
出版信息
Lancet. 1987 Dec 12;2(8572):1354-8. doi: 10.1016/s0140-6736(87)91255-4.
A viral infection characterised by serum HBsAg positivity with serum anti-HBc negativity has been encountered in Senegal. The infection is not associated with the presence of HBeAg, so it differs from hepatitis B virus in its core antigen, but the surface antigen of the two viruses share some epitopes. After the loss of HBsAg, neither anti-HBc nor anti-HBs becomes detectable. Anti-HBs, naturally acquired or produced by immunisation, does not protect against this new infection. Chronic carriage occurs. If this new infection is confirmed to cause chronic liver disease, hepatitis B vaccine should include surface antigen from the new virus.
在塞内加尔发现了一种病毒感染，其特征为血清乙肝表面抗原（HBsAg）呈阳性，而血清抗乙肝核心抗体（anti-HBc）呈阴性。这种感染与乙肝e抗原（HBeAg）的存在无关，因此在核心抗原方面与乙肝病毒不同，但两种病毒的表面抗原具有一些共同表位。在HBsAg消失后，抗HBc和抗HBs均无法检测到。自然获得或通过免疫产生的抗HBs不能预防这种新感染。会出现慢性携带状态。如果证实这种新感染会导致慢性肝病，乙肝疫苗应包含来自这种新病毒的表面抗原。
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