Cancer Research UK Clinical Centre, University of Leeds, St James's Institute of Oncology, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UK.
Comput Biol Med. 2011 Aug;41(8):575-86. doi: 10.1016/j.compbiomed.2011.04.014. Epub 2011 Jun 23.
Secondary use of patient databases is essential in healthcare if clinical trials are to progress efficiently to planned time and target and imperative if the planned UK expansion of research and development (R&D) at point of care is to be achieved. Integration of effective databases primarily designed to facilitate patient care with R&D requirements is needed but represents a complex challenge. We present a system that achieves an integrated approach with online management of complex datasets for clinical trials within care records using a specific study as an example to show functionality in practice; illustrating how this system provides an ideal resource to meet the needs of both clinicians and researchers.
如果要使临床试验按计划的时间和目标高效推进，那么在医疗保健中二次利用患者数据库至关重要；如果要实现英国计划在医疗点扩大研发（R&D），这也是必要的。需要将主要用于促进患者护理的有效数据库与研发需求进行整合，但这是一个复杂的挑战。我们提出了一个系统，该系统通过使用特定研究作为示例在护理记录中在线管理临床试验的复杂数据集，实现了一种集成方法，展示了该系统在实践中的功能；说明了该系统如何为临床医生和研究人员提供理想的资源来满足他们的需求。
