Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Leuk Res. 2011 Oct;35(10):1297-300. doi: 10.1016/j.leukres.2011.05.002. Epub 2011 Jun 23.
To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis.
为了进一步研究 Y 染色体丢失作为唯一骨髓核型改变的潜在临床意义，我们研究了 161 例 Mayo 诊所的男性患者，这些患者的中期细胞中有 75%或更多的 Y 染色体丢失，并将 Y 染色体丢失的百分比与年龄和血液病理学检查结果相关联。在患有淋巴增生性或浆细胞疾病的患者中，骨髓受累的比例可以忽略不计，这不能解释观察到的高比例-Y 细胞。在患有髓系疾病的男性中，Y 染色体丢失似乎经常代表异常髓系克隆，该克隆可能还携带通过常规细胞遗传学分析无法观察到的获得性遗传改变。
