Department of Animal and Plant Sciences, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK.
J Infect. 2011 Sep;63(3):200-6. doi: 10.1016/j.jinf.2011.06.005. Epub 2011 Jun 16.
Many fundamental patterns of coinfection (multi-species infections) are undescribed, including the relative frequency of coinfection by various pathogens, differences between single-species infections and coinfection, and the burden of coinfection on human health. We aimed to address the paucity of general knowledge on coinfection by systematically collating and analysing data from recent publications to understand the types of coinfection and their effects.
From an electronic search to find all publications from 2009 on coinfection and its synonyms in humans we recorded data on i) coinfecting pathogens and their effect on ii) host health and iii) intensity of infection.
The most commonly reported coinfections differ from infections causing highest global mortality, with a notable lack of serious childhood infections in reported coinfections. We found that coinfection is generally reported to worsen human health (76% publications) and exacerbate infections (57% publications). Reported coinfections included all kinds of pathogens, but were most likely to contain bacteria.
These results suggest differences between coinfected patients and those with single infections, with coinfection having serious health effects. There is a pressing need to quantify the tendency towards negative effects and to evaluate any sampling biases in the coverage of coinfection research.
许多基本的混合感染（多种病原体感染）模式尚未被描述，包括各种病原体混合感染的相对频率、单重感染和混合感染之间的差异，以及混合感染对人类健康的负担。我们旨在通过系统地整理和分析最近出版物中的数据来解决混合感染知识匮乏的问题，以了解混合感染的类型及其影响。
我们从电子搜索中找到了 2009 年以来所有关于人类混合感染及其同义词的出版物，并记录了以下数据：i）混合感染的病原体及其对 ii）宿主健康和 iii）感染强度的影响。
最常报告的混合感染与导致最高全球死亡率的感染不同，报告的混合感染中明显缺乏严重的儿童感染。我们发现混合感染通常会导致人类健康状况恶化（76%的出版物）并加重感染（57%的出版物）。报告的混合感染包括各种病原体，但最有可能包含细菌。
这些结果表明混合感染患者与单一感染患者之间存在差异，混合感染对健康有严重影响。迫切需要量化负面效果的倾向，并评估混合感染研究中任何抽样偏差。
