Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
Acad Radiol. 2011 Sep;18(9):1151-8. doi: 10.1016/j.acra.2011.05.004. Epub 2011 Jun 24.
To detect whether the efficacy of microwave ablation (MWA) could be improved by preinjected fluids in an ex vivo porcine liver model.
Ablations were performed for 12 minutes using energy output of impedance-based (power output gradually rose to 200W, maintained until increases in tissue impedance of 20 Ω, reduced to 10W, and switched on again 15 seconds later) in radiofrequency ablation (RFA) or 80 W in MWA. Before ablation, 5 mL of ethanol, distilled water, 0.9% NaCl solution, or 10% NaCl solution (n = 6 each) was injected into the targeted liver tissue. Ablations without fluid injection served as control. The ablation diameter, volume, shape index, and temperature were recorded and compared.
Preinjection of 0.9% or 10% NaCl solution resulted in larger coagulation volumes than that of the control group in RFA experiments (28.1 ± 2.9 cm(3), 45.3 ± 6.3 cm(3), 20.0 ± 2.5 cm(3), respectively; P < .05). Ethanol and distilled water had no impact on coagulation volumes in RFA. Preinjection of ethanol or 10% NaCl solution created smaller coagulation volumes than that of the control group in MWA experiments (34.3 ± 2.0 cm(3), 33.9 ± 4.1 cm(3), 58.0 ± 6.6 cm(3), respectively; P < .001). 0.9% NaCl solution and distilled water had no impact on coagulation volumes in MWA.
In an ex vivo porcine liver, preinjected fluids do not benefit microwave ablation as those in radiofrequency ablation.
在离体猪肝模型中检测预先注射液体是否能提高微波消融（MWA）的疗效。
使用基于阻抗的射频消融（RFA）能量输出（功率输出逐渐升高至 200W，维持至组织阻抗增加 20 Ω，降至 10W，15 秒后再次开启）或 MWA 中的 80W 进行 12 分钟消融。在消融前，将 5ml 乙醇、蒸馏水、0.9%NaCl 溶液或 10%NaCl 溶液（每组各 6 个）注入靶肝组织。未注射液体的消融作为对照。记录和比较消融直径、体积、形状指数和温度。
在 RFA 实验中，0.9%或 10%NaCl 溶液的预先注射导致凝固体积大于对照组（28.1 ± 2.9cm³、45.3 ± 6.3cm³、20.0 ± 2.5cm³，P<.05）。乙醇和蒸馏水对 RFA 中的凝固体积没有影响。在 MWA 实验中，乙醇或 10%NaCl 溶液的预先注射导致凝固体积小于对照组（34.3 ± 2.0cm³、33.9 ± 4.1cm³、58.0 ± 6.6cm³，P<.001）。0.9%NaCl 溶液和蒸馏水对 MWA 中的凝固体积没有影响。
在离体猪肝中，预先注射的液体不能像在射频消融中那样有益于微波消融。
