Department of Genetics, Harvard Medical School, Massachusetts General Hospital, MA 02114, USA.
Curr Opin Plant Biol. 2011 Oct;14(5):519-29. doi: 10.1016/j.pbi.2011.05.006. Epub 2011 Jun 23.
In plants and animals, innate immunity is triggered through pattern recognition receptors (PRRs) in response to microbe-associated molecular patterns (MAMPs) to provide the first line of inducible defense. Plant receptor protein kinases (RPKs) represent the main plasma membrane PRRs perceiving diverse MAMPs. RPKs also recognize secondary danger-inducible plant peptides and cell-wall signals. Both types of RPKs trigger rapid and convergent downstream signaling networks controlled by calcium-activated PKs and mitogen-activated PK (MAPK) cascades. These PK signaling networks serve specific and overlapping roles in controlling the activities and synthesis of a plethora of transcription factors (TFs), enzymes, hormones, peptides and antimicrobial chemicals, contributing to resistance against bacteria, oomycetes and fungi.
在动植物中，先天免疫是通过模式识别受体 (PRR) 对微生物相关分子模式 (MAMP) 的反应触发的，为诱导防御提供第一道防线。植物受体蛋白激酶 (RPK) 是感知各种 MAMP 的主要质膜 PRR。RPK 还识别次级危险诱导的植物肽和细胞壁信号。这两种类型的 RPK 触发由钙激活的 PK 和丝裂原激活的 PK (MAPK) 级联控制的快速和收敛的下游信号网络。这些 PK 信号网络在控制大量转录因子 (TF)、酶、激素、肽和抗菌化学物质的活性和合成方面发挥特定和重叠的作用，有助于抵抗细菌、卵菌和真菌。
