Domizio P, Talbot I C, Spigelman A D, Williams C B, Phillips R K
Department of Histopathology, St Mark's Hospital, London.
J Clin Pathol. 1990 Sep;43(9):738-43. doi: 10.1136/jcp.43.9.738.
Multiple gastric and duodenal biopsy specimens from 102 asymptomatic patients with familial adenomatous polyposis, taken during a prospective endoscopic screening programme were examined. One hundred patients had microscopic gastroduodenal pathology, often in the absence of macroscopic lesions. Adenomas were found in 94 patients in the duodenum, in the second and third parts. Hyperplasia of villous and crypt epithelium was also seen, sometimes in the absence of adenomas: this may be a precursor of neoplastic change. In the stomach fundic gland polyps were the commonest abnormality, seen microscopically in 44 patients. Chronic antral gastritis was common in patients without fundic polyps. Gastric adenomas were present in six patients, all of whom also had duodenal adenomas. If duodenal adenomas in familial adenomatous polyposis have a similar malignant potential to those in the colorectum sequential endoscopy and biopsy are necessary to detect cancer in these patients.
在一项前瞻性内镜筛查计划中，对102例无症状家族性腺瘤性息肉病患者的多个胃和十二指肠活检标本进行了检查。100例患者存在胃十二指肠微观病理改变，通常无宏观病变。94例患者在十二指肠第二和第三部分发现腺瘤。还可见绒毛和隐窝上皮增生，有时无腺瘤：这可能是肿瘤性改变的前驱病变。在胃中，胃底腺息肉是最常见的异常，44例患者在显微镜下可见。无胃底息肉的患者常见慢性胃窦炎。6例患者存在胃腺瘤，所有这些患者也有十二指肠腺瘤。如果家族性腺瘤性息肉病中的十二指肠腺瘤与结直肠癌中的腺瘤具有相似的恶性潜能，则需要进行序贯内镜检查和活检以检测这些患者中的癌症。
