Sipponen P, Laxén F, Seppälä K
Histopathology. 1983 Sep;7(5):729-37. doi: 10.1111/j.1365-2559.1983.tb02285.x.
In 1977, Elster et al. described gastric polyps of a new type. These polyps were formed of fundic glandular cysts in otherwise normal gastric mucosa. In this paper a series of 52 cases of this type of polyp are presented. In addition to cysts, polyps contained deformed oxyntic glands and areas where the formation of secondary irregular glands occurred from cysts and from the existing glands. However, all glands and cysts in polyps were composed of normal, but intermixed cells of oxyntic type, suggesting that deranged differentiation of otherwise normal oxyntic glands is the basic mechanism in the pathogenesis of these polyps. Based on these observations, the polyps were considered most likely to be epithelial hamartomas. In agreement with the findings of Elster et al., the present cases showed typical clinical characteristics: three-quarters of patients were females with a peak prevalence in the fifth and sixth decades. Polyps were most often multiple and occurred only in the oxyntic mucosa of the stomach.
1977年，埃尔斯特等人描述了一种新型胃息肉。这些息肉由胃黏膜正常但含有胃底腺囊肿构成。本文报告了52例此类息肉病例。除囊肿外，息肉还包含变形的壁细胞腺以及囊肿和现有腺体形成继发性不规则腺体的区域。然而，息肉中的所有腺体和囊肿均由正常但混合的壁细胞类型细胞组成，这表明正常壁细胞腺的分化紊乱是这些息肉发病机制的基本机制。基于这些观察结果，这些息肉最有可能被认为是上皮错构瘤。与埃尔斯特等人的研究结果一致，本病例显示出典型的临床特征：四分之三的患者为女性，发病高峰在第五和第六个十年。息肉最常为多发，且仅发生于胃的壁细胞黏膜。
