Nuovo G J, Lastarria D A, Smith S, Lerner J, Comité S L, Eliezri Y D
Department of Pathology, Columbia Presbyterian Medical Center, New York, New York.
Am J Clin Pathol. 1991 Apr;95(4):467-74. doi: 10.1093/ajcp/95.4.467.
This study compared the segregation patterns of human papillomavirus (HPV) in genital and nongenital warts in prepubertal children and adults. HPV 2 was detected in most nongenital warts in children and adults, whereas neither HPV 6 or 11 was detected at nongenital sites in either group with the use of in situ or Southern blot hybridization analyses. Of nine genital tract lesions in children. HPV 2 was detected in two and HPV 6 or 11 in six. More than 90% of cases of regional tract condylomata in adults contained HPV 6 or 11. HPV 2 was not detected in any of 99 genital tract lesions in adults. It is concluded that HPV 6/11 cannot proliferate at nongenital cutaneous sites and HPV 2 can proliferate in the genital tract of children but not adults. Thus, the detection of HPV 6 or 11 in a genital wart in a child implies, assuming cutaneous transmission, infection from a genital site, whereas the detection of HPV 2 presumes nongenital transmission.
本研究比较了人乳头瘤病毒（HPV）在青春期前儿童和成人的生殖器疣与非生殖器疣中的分离模式。在儿童和成人的大多数非生殖器疣中检测到HPV 2，而通过原位杂交或Southern印迹杂交分析，在两组的非生殖器部位均未检测到HPV 6或11。在儿童的9个生殖道病变中，2个检测到HPV 2，6个检测到HPV 6或11。成人中超过90%的区域生殖道尖锐湿疣病例含有HPV 6或11。在成人的99个生殖道病变中均未检测到HPV 2。得出的结论是，HPV 6/11不能在非生殖器皮肤部位增殖，HPV 2可以在儿童而非成人的生殖道中增殖。因此，在儿童的生殖器疣中检测到HPV 6或11（假设为皮肤传播）意味着是从生殖器部位感染的，而检测到HPV 2则推测为非生殖器传播。
