Institute for Research Organization, Hungarian Academy of Sciences, Budapest, Hungary.
Am J Obstet Gynecol. 2011 Oct;205(4):362.e26-31. doi: 10.1016/j.ajog.2011.05.012. Epub 2011 May 12.
The purpose of this study was to demonstrate that daily 40-minute whole body exposure to an inhomogeneous static magnetic field (SMF) prolongs induced preterm birth (PTB) in mice.
The murine model for PTB induction was performed by the administration of 25 μg/animal lipopolysaccharide (LPS) intraperitoneally. The applied SMF was an inhomogeneous gradient field with 2.8-476.7 millitesla peak-to-peak magnetic induction range by 10 mm lateral periodicity. During SMF exposure, mice were free to move in their cage.
The fetal development and the delivery were normal in animals that were exposed to SMF but not treated with LPS. SMF in these cases did not influence the term of delivery. In LPS-challenged animals, SMF exposure prolonged the time of PTB occurrence from 17.43 h (n = 7) to 21.93 h (n = 15) after the challenge (P < .05).
Exposure to inhomogeneous SMF may have a valuable effect in the prevention of PTB and may have clinical relevance to humans.
本研究旨在证明每天 40 分钟全身暴露于非均匀静态磁场（SMF）可延长小鼠诱导性早产（PTB）。
通过腹腔内给予 25μg/动物脂多糖（LPS）来进行 PTB 诱导的小鼠模型。应用的 SMF 是一种具有 2.8-476.7 毫特斯拉峰峰值磁感应强度的非均匀梯度场，横向周期性为 10 毫米。在 SMF 暴露期间，小鼠可以在笼子里自由移动。
在接受 SMF 但未接受 LPS 处理的动物中，胎儿发育和分娩正常。在这些情况下，SMF 并未影响分娩时间。在 LPS 挑战的动物中，SMF 暴露将 PTB 发生的时间从 LPS 挑战后 17.43 小时（n = 7）延长至 21.93 小时（n = 15）（P <.05）。
暴露于非均匀 SMF 可能对预防 PTB 有有益的影响，并且可能对人类具有临床相关性。
