Juhász Márk, Nagy Viktor L, Székely Hajnal, Kocsis Dorottya, Tulassay Zsolt, László János F
2nd Department of Internal Medicine, Semmelweis University, Budapest, Szentkirályi u. 46, 1088, Hungary.
e-Comers LLC, Csejtei u. 1-3, Budapest 1025, Hungary Department of Computer Science, University of Debrecen, Kassai út 26, Debrecen 4028, Hungary
J R Soc Interface. 2014 Sep 6;11(98):20140601. doi: 10.1098/rsif.2014.0601.
This pilot study was devoted to the effect of static magnetic field (SMF)-exposure on erosive gastritis. The randomized, self- and placebo-controlled, double-blind, pilot study included 16 patients of the 2nd Department of Internal Medicine, Semmelweis University diagnosed with erosive gastritis. The instrumental analysis followed a qualitative (pre-intervention) assessment of the symptoms by the patient: lower heartburn (in the ventricle), upper heartburn (in the oesophagus), epigastric pain, regurgitation, bloating and dry cough. Medical diagnosis included a double-line upper panendoscopy followed by 30 min local inhomogeneous SMF-exposure intervention at the lower sternal region over the stomach with peak-to-peak magnetic induction of 3 mT and 30 mT m(-1) gradient at the target site. A qualitative (post-intervention) assessment of the same symptoms closed the examination. Sham- or SMF-exposure was used in a double-blind manner. The authors succeeded in justifying the clinically and statistically significant beneficial effect of the SMF- over sham-exposure on the symptoms of erosive gastritis, the average effect of inhibition was 56% by p = 0.001, n = 42 + 96. This pilot study was aimed to encourage gastroenterologists to test local, inhomogeneous SMF-exposure on erosive gastritis patients, so this intervention may become an evidence-based alternative or complementary method in the clinical use especially in cases when conventional therapy options are contraindicated.
这项前瞻性研究致力于探讨静磁场（SMF）暴露对糜烂性胃炎的影响。该随机、自身及安慰剂对照、双盲的前瞻性研究纳入了塞梅尔维斯大学第二内科诊断为糜烂性胃炎的16例患者。仪器分析之前，患者对症状进行了定性（干预前）评估：下烧灼感（在胃部）、上烧灼感（在食管）、上腹部疼痛、反流、腹胀和干咳。医学诊断包括双线式上消化道内镜检查，随后在胃部胸骨下区域进行30分钟局部不均匀SMF暴露干预，目标部位的峰-峰磁感应强度为3 mT，梯度为30 mT m(-1)。对相同症状进行定性（干预后）评估以结束检查。采用双盲方式进行假暴露或SMF暴露。作者成功证明了SMF暴露相对于假暴露对糜烂性胃炎症状具有临床和统计学意义的有益效果，抑制的平均效果为56%，p = 0.001，n = 42 + 96。这项前瞻性研究旨在鼓励胃肠病学家对糜烂性胃炎患者进行局部不均匀SMF暴露测试，因此这种干预可能成为临床应用中基于证据的替代或补充方法，尤其是在常规治疗方案禁忌的情况下。
