Memeh C U
Department of Physiology, School of Medicine, College of Medical Sciences, University of Benin, Nigeria.
J Hypertens. 1990 Aug;8(8):711-4. doi: 10.1097/00004872-199008000-00004.
Plasma viscosity and fibrinogen concentrations were measured in 70 diabetics (35 hypertensive and 35 normotensive) and compared with those of 35 age- and sex-matched normotensive healthy subjects in relation to body weight. The body weight, body mass index, blood pressure (systolic and diastolic), mean arterial pressure, plasma viscosity and fibrinogen level of the hypertensive diabetics were significantly higher than the values seen in the controls. Among the normotensive diabetics, only the fibrinogen concentration was elevated above that of the controls (P less than 0.01). Body weight, body mass index, blood pressure (systolic and diastolic), mean arterial pressure and plasma viscosity were all significantly higher in the hypertensive diabetics than in their normotensive counterparts. The difference in fibrinogen titre of both groups of diabetics was not significant. Body mass index, fibrinogen and plasma viscosity were correlated significantly with systolic and diastolic blood pressures (P less than 0.001). The order of relative contribution showed that fibrinogen contributed most to blood pressure, followed by plasma viscosity and then body mass index. The results suggest that high levels of body weight, fibrinogen concentration and plasma viscosity could contribute to the development of hypertension in diabetic Nigerians.
对70名糖尿病患者（35名高血压患者和35名血压正常者）测量了血浆粘度和纤维蛋白原浓度，并将其与35名年龄和性别匹配的血压正常的健康受试者按体重进行比较。高血压糖尿病患者的体重、体重指数、血压（收缩压和舒张压）、平均动脉压、血浆粘度和纤维蛋白原水平显著高于对照组。在血压正常的糖尿病患者中，只有纤维蛋白原浓度高于对照组（P小于0.01）。高血压糖尿病患者的体重、体重指数、血压（收缩压和舒张压）、平均动脉压和血浆粘度均显著高于血压正常的糖尿病患者。两组糖尿病患者的纤维蛋白原滴度差异不显著。体重指数、纤维蛋白原和血浆粘度与收缩压和舒张压显著相关（P小于0.001）。相对贡献顺序表明，纤维蛋白原对血压的贡献最大，其次是血浆粘度，然后是体重指数。结果表明，高体重、纤维蛋白原浓度和血浆粘度可能有助于尼日利亚糖尿病患者高血压的发生。
