Department of Orthopaedic Surgery, National Hospital Organization Osaka Minami Medical Center, 2-1 Kidohigashi, Kawachinagano, Osaka 586-8521, Japan.
Arch Orthop Trauma Surg. 2011 Nov;131(11):1499-507. doi: 10.1007/s00402-011-1343-0. Epub 2011 Jun 26.
We reported that excessive disc space distraction caused by insertion of large cages during posterior lumbar interbody fusion (PLIF) combined with pedicle screws (PS) induces adjacent segment disease (ASD). Spinous process plate (SPP) is known to allow cage subsidence when used in PLIF, since they cannot share vertical loads. We therefore hypothesize that the incidence of ASD after PLIF with SPP should be lower than that after PLIF with PS due to this loss of disc space distraction.
Radiographic ASD is defined as development of spondylolisthesis > 3 mm, decrease in disc height > 3 mm, or intervertebral angle at flexion lesser than -5°. Symptomatic ASD is defined by a decrease of ≥ 4 points in Japanese Orthopedic Association score. One hundred and thirty patients with L4 spondylolisthesis were treated with either PLIF with SPP (n = 45) or PLIF with PS (n = 85) and followed up for a minimum of 2 years (mean, 39.0 months).
L4-5 disc space distraction in the SPP group was significantly smaller (0.4 mm) as compared to the PS group (1.8 mm). The incidence of clinical ASD in the SPP group (2%, 1/45) was also significantly less than that in the PS group (15%, 13/85). Multivariate analysis showed that disc space distraction was the most significant risk factor.
Among various risk factors for ASD after PLIF, the excessive distraction of disc space proved to be a potent risk factor for ASD.
我们曾报道,后路腰椎间融合术(PLIF)联合椎弓根螺钉(PS)置入大 cage 时,过度的椎间盘空间分离会导致邻近节段疾病(ASD)。已知棘突板(SPP)在 PLIF 中使用时会导致 cage 下沉,因为它们不能分担垂直载荷。因此,我们假设由于这种椎间盘空间分离的丧失,使用 SPP 的 PLIF 后 ASD 的发生率应低于使用 PS 的 PLIF。
影像学 ASD 的定义为滑脱>3mm,椎间盘高度降低>3mm,或屈曲时椎间角< -5°。症状性 ASD 的定义为日本矫形协会评分降低≥4 分。130 例 L4 滑脱患者接受 SPP 辅助的 PLIF(n=45)或 PS 辅助的 PLIF(n=85)治疗,并至少随访 2 年(平均 39.0 个月)。
与 PS 组(1.8mm)相比,SPP 组 L4-5 椎间盘空间分离明显较小(0.4mm)。SPP 组临床 ASD 的发生率(2%,1/45)也明显低于 PS 组(15%,13/85)。多因素分析显示,椎间盘空间分离是最显著的危险因素。
在 PLIF 后 ASD 的各种危险因素中,椎间盘空间的过度分离被证明是 ASD 的一个潜在危险因素。