[油症患者有丝分裂原诱导的淋巴细胞转化受损]

[Impaired mitogen-induced lymphocyte transformation in patients with Yusho].

作者信息

Tsuji Hiroshi, Ito Yasuo

机构信息

Department of Internal Medicine, Kitakyushu-Tsuyazaki Hospital, Fukuoka 811-3307, Japan.

出版信息

Fukuoka Igaku Zasshi. 2011 Apr;102(4):81-6.

PMID:21706884

Abstract

To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), in vitro lymphocyte transformation in response to phytohemagglutinin (PHA) and concanavalin A (Con A) was studied in 139 patients with Yusho and 61 controls. PHA-induced lymphocyte transformation was significantly lower in patients with Yusho than in controls. PHA-induced lymphocyte transformation was inversely correlated with the concentrations of PCB and 2,3,4,7, 8-pentachlorodibenzofuran (PeCDF) in the blood. Con A-induced lymphocyte transformation showed similar inverse correlations with the concentrations of PCB and 2,3,4,7, 8-PeCDF. We conclude that impairment of mitogen-induced lymphocyte transformation in patients with Yusho may be associated with PCB and 2,3,4,7,8-PeCDF in the blood.

摘要

为了研究多氯联苯（PCB）和多氯二苯并呋喃（PCDF）的慢性免疫效应，我们对139名油症患者和61名对照者进行了研究，检测了他们的淋巴细胞对植物血凝素（PHA）和刀豆蛋白A（Con A）的体外转化反应。油症患者中PHA诱导的淋巴细胞转化显著低于对照组。PHA诱导的淋巴细胞转化与血液中PCB和2,3,4,7,8 - 五氯二苯并呋喃（PeCDF）的浓度呈负相关。Con A诱导的淋巴细胞转化与PCB和2,3,4,7,8 - PeCDF的浓度也呈现出类似的负相关。我们得出结论，油症患者中丝裂原诱导的淋巴细胞转化受损可能与血液中的PCB和2,3,4,7,8 - PeCDF有关。