Masuda Y, Haraguchi K, Kuroki H, Ryan J J
Daiichi College of Pharmaceutical Sciences, Fukuoka.
Fukuoka Igaku Zasshi. 1995 May;86(5):178-83.
The blood samples of 3 Yucheng patients collected 6-7 times from 1980 to 1993 and 5 Yusho patients collected 6-8 times from 1982 to 1993 were analyzed for congeners of polychlorinated dibenzofurans (PCDF) and polychlorinated biphenyls (PCB) by high resolution gas chromatography-mass spectrometry and gas chromatography-electron capture detection. In the blood of Yucheng patients, the high concentrations of 3 PCDF congeners, 2,3',4, 4',5-penta-CB and 5 PCB congeners were eliminated at half-lives of 2.4-2.9, 1.7 and 4.1-6.1 years, respectively, while in Yusho patients, 14 years after the incident, their half-lives were converted to longer times as observed 3.2-13.4, 24.0 and 13.7-34.2 years, respectively. In the same Yucheng and Yusho patients, the half-lives of the 5 PCB congeners were about twice longer than those of the 3 PCDF congeners. PCBs are more retainable than PCDFs in human blood.
1980年至1993年间，对3名禹城患者采集了6 - 7次血样，1982年至1993年间，对5名油症患者采集了6 - 8次血样，采用高分辨率气相色谱 - 质谱联用仪和气相色谱 - 电子捕获检测器分析了多氯二苯并呋喃（PCDF）和多氯联苯（PCB）的同系物。在禹城患者的血液中，3种PCDF同系物、2,3',4,4',5 - 五氯联苯和5种PCB同系物的高浓度分别以2.4 - 2.9年、1.7年和4.1 - 6.1年的半衰期消除，而在油症患者中，事发14年后，它们的半衰期分别转变为更长的时间，即3.2 - 13.4年、24.0年和13.7 - 34.2年。在同一些禹城和油症患者中，5种PCB同系物的半衰期约为3种PCDF同系物半衰期的两倍。多氯联苯在人体血液中的留存性比多氯二苯并呋喃更强。
