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具有I亚组特异性和长RNA模式的人轮状病毒VP4和VP7基因的核苷酸序列：对新G血清型特异性的意义。

Nucleotide sequence of VP4 and VP7 genes of human rotaviruses with subgroup I specificity and long RNA pattern: implication for new G serotype specificity.

作者信息

Taniguchi K, Urasawa T, Kobayashi N, Gorziglia M, Urasawa S

机构信息

Department of Hygiene, Sapporo Medical College, Japan.

出版信息

J Virol. 1990 Nov;64(11):5640-4. doi: 10.1128/JVI.64.11.5640-5644.1990.

DOI:10.1128/JVI.64.11.5640-5644.1990
PMID:2170690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248620/
Abstract

We sequenced the genes coding for the two neutralization proteins, VP4 and VP7, of human rotavirus strains L26 and L27 with subgroup I specificity but the long RNA pattern. The deduced VP7 amino acid sequence of strains L26 and L27 showed a low homology (73.6 to 81.9%) to those of rotavirus strains of the established serotypes. This finding, together with the previous serological characterizations, suggests that the VP7 (G) serotype of the L26 and L27 strains is distinct from those of strains of the previously established serotypes. In contrast, the VP4 sequences of the L26 and L27 strains were quite similar to those of virulent serotype 2 strains (DS-1, S2, and RV-5).

摘要

我们对具有I亚组特异性但长RNA模式的人轮状病毒L26和L27株编码两种中和蛋白VP4和VP7的基因进行了测序。L26和L27株推导的VP7氨基酸序列与已确立血清型的轮状病毒株的序列显示出较低的同源性（73.6%至81.9%）。这一发现与先前的血清学特征一起表明，L26和L27株的VP7（G）血清型与先前确立的血清型的毒株不同。相比之下，L26和L27株的VP4序列与强毒株血清型2株（DS-1、S2和RV-5）的序列非常相似。

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Serotype determination of human rotavirus isolates and antibody prevalence in pediatric population in Hokkaido, Japan.日本北海道儿童人群中人类轮状病毒分离株的血清型测定及抗体流行情况
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