Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, UK.
Expert Rev Mol Diagn. 2011 Jun;11(5):497-503. doi: 10.1586/erm.11.31.
The ability to monitor blood glucose noninvasively has long been a goal of those with diabetes, due to the pain and inconvenience of current blood glucose monitoring devices. This article investigates the potential for monitoring compounds in breath and emitted through skin for inferring blood glucose concentration. Potential markers and an assessment of their suitability for noninvasive monitoring are discussed. The varying technologies developed for monitoring volatile organic compounds in breath and from the skin of diabetics and their suitability for development as a hand-held device is reviewed. The potential exists for the use of breath and skin monitoring as an alternative to blood glucose, but it may take years to collect sufficient clinical data for robust correlations to be possible.
长期以来，由于目前血糖监测设备的疼痛和不便，非侵入性监测血糖的能力一直是糖尿病患者的目标。本文研究了通过监测呼吸中的化合物并通过皮肤排放来推断血糖浓度的可能性。讨论了潜在的标志物及其对非侵入性监测的适用性评估。评估了为监测糖尿病患者呼吸中的挥发性有机化合物和皮肤中开发的各种技术，以及它们作为手持式设备开发的适用性。使用呼吸和皮肤监测作为血糖的替代方法是可能的，但可能需要数年时间才能收集到足够的临床数据以实现可靠的相关性。
