Department of Anaesthesia, CUB Hopital Erasme, Brussels, Belgium.
Acta Anaesthesiol Scand. 2011 Sep;55(8):927-43. doi: 10.1111/j.1399-6576.2011.02471.x. Epub 2011 Jun 27.
We calculated in a meta-analysis the effect size for the reduction of post-operative pain and post-operative analgesic drugs, which can be obtained by the perioperative administration of pregabalin. Three end-points of efficacy were analysed: early (6 h-7 days) post-operative pain at rest (17 studies) and during movement (seven studies), and the amount of analgesic drugs in the studies that obtained identical results for pain at rest (12 studies). Reported adverse effects were also analysed. The daily dose of pregabalin ranged from 50 to 750 mg/day. The duration of treatment in patients assessed for pain ranged from a single administration to 2 weeks. Pregabalin administration reduced the amount of post-operative analgesic drugs (30.8% of non-overlapping values - odds ratio=0.43). There was no effect with 150, and 300 or 600 mg/day provided identical results. Pregabalin increased the risk of dizziness or light-headedness and of visual disturbances, and decreased the occurrence of post-operative nausea and vomiting (PONV) in patients who did not receive anti-PONV prophylaxis. The administration of pregabalin during a short perioperative period provides additional analgesia in the short term, but at the cost of additional adverse effects. The lowest effective dose was 225-300 mg/day.
我们通过荟萃分析计算了普瑞巴林围手术期给药在减轻术后疼痛和术后镇痛药物方面的效果大小。分析了三个疗效终点：早期（6 小时-7 天）静息（17 项研究）和运动时（7 项研究）的术后疼痛，以及在获得静息疼痛相同结果的研究中（12 项研究）镇痛药物的用量。还分析了报告的不良反应。普瑞巴林的日剂量范围为 50 至 750 毫克/天。评估疼痛的患者的治疗持续时间从单次给药到 2 周不等。普瑞巴林给药减少了术后镇痛药物的用量（非重叠值的 30.8% - 优势比=0.43）。150 毫克/天没有效果，而 300 或 600 毫克/天的效果相同。普瑞巴林增加了头晕或头晕以及视觉障碍的风险，并降低了未接受止吐预防的患者术后恶心和呕吐（PONV）的发生率。在短的围手术期内给予普瑞巴林可在短期内提供额外的镇痛作用，但代价是增加不良反应的风险。最低有效剂量为 225-300 毫克/天。
