First Department for Skin and Venereal Diseases, Andreas Syggros Hospital, National and Capodistrian University of Athens-Medical School, Athens, Greece.
J Eur Acad Dermatol Venereol. 2012 Jun;26(6):762-7. doi: 10.1111/j.1468-3083.2011.04161.x. Epub 2011 Jun 28.
Calcineurin inhibitors show potent anti-inflammatory effects and favorable safety profile when used in the treatment of cutaneous lupus erythematosus (CLE).
The present study investigates the change in clinical parameters of erythema, desquamation and edema, when calcineurin inhibitors are used as monotherapy or in combination with hydroxychloroquine in CLE for a period of 60 days.
18 patients were treated with topical tacrolimus and 20 patients with topical pimecrolimus, as monotherapy or in combination with hydroxychloroquine. Clinical parameters of erythema, desquamation and edema were assessed on a scale from 0 to 3 for erythema and edema and 0 to 2 for desquamation.
Statistically significant improvement in erythema, desquamation and edema was observed in patients on monotherapy with calcineurin inhibitor and combination treatment with hydroxychloroquine, regardless of disease type. Combination treatment resulted in improvement of edema in 100% of patients, while monotherapy did so in 75% of patients.
Topical calcineurin inhibitors enhance the therapeutic effect of systemic agents in cutaneous lupus erythematosus, and result in improvement of the clinical parameters studied.
钙调磷酸酶抑制剂在治疗红斑狼疮时具有强大的抗炎作用和良好的安全性。
本研究旨在探讨钙调磷酸酶抑制剂在治疗红斑狼疮 60 天内作为单一疗法或与羟氯喹联合应用时，对红斑、脱屑和水肿等临床参数的变化。
18 例患者接受他克莫司乳膏治疗，20 例患者接受吡美莫司乳膏治疗，作为单一疗法或与羟氯喹联合应用。采用 0-3 分评估红斑和水肿的红斑和水肿程度，0-2 分评估脱屑程度。
无论疾病类型如何，接受钙调磷酸酶抑制剂单一治疗和联合羟氯喹治疗的患者，红斑、脱屑和水肿均有显著改善。联合治疗可使 100%的患者水肿得到改善，而单一治疗则使 75%的患者水肿得到改善。
局部钙调磷酸酶抑制剂增强了系统性药物在红斑狼疮中的治疗效果，并改善了所研究的临床参数。
