Genant H K, Baylink D J, Gallagher J C, Harris S T, Steiger P, Herber M
Department of Radiology, University of California, San Francisco 94143.
Obstet Gynecol. 1990 Oct;76(4):579-84.
Estrogen replacement therapy confers many beneficial effects to postmenopausal women, such as slowing the rate of bone loss and decreasing the risk of coronary artery disease. This multicenter, placebo-controlled study evaluated the lowest effective daily dose of estrone sulfate (0.3, 0.625, or 1.25 mg) combined with 1000 mg elemental calcium supplementation for preventing bone loss in the immediate supplementation for preventing bone loss in the immediate postmenopausal period. Spinal bone mineral density was measured using quantitative computed tomography. Compared with baseline, bone mineral density increased significantly (P less than .05) after 12 months of 0.625 mg daily (+ 1.9%) or 1.25 mg daily (+ 2.5%). The difference between the 0.625-mg and 1.25-mg doses was not statistically significant. Estrone sulfate administration (0.625 and 1.25 mg) produced significant changes in various lipid measurements at both the 6- and 12-month observation points. The prevalence rates for adverse events were comparable among the estrone sulfate groups and the placebo group. Estrone sulfate 0.625 mg daily, combined with 1000 mg elemental calcium supplementation, was the minimum effective dosage to prevent loss of spinal bone mineral density in postmenopausal women over a 12-month period.
雌激素替代疗法对绝经后女性有许多益处，比如减缓骨质流失速度以及降低冠状动脉疾病风险。这项多中心、安慰剂对照研究评估了硫酸雌酮的最低有效日剂量（0.3、0.625或1.25毫克）联合补充1000毫克元素钙在绝经后即刻预防骨质流失的效果。使用定量计算机断层扫描测量脊柱骨密度。与基线相比，每日服用0.625毫克（增加1.9%）或1.25毫克（增加2.5%）12个月后，骨密度显著增加（P小于0.05）。0.625毫克和1.25毫克剂量之间的差异无统计学意义。在6个月和12个月观察点，服用硫酸雌酮（0.625毫克和1.25毫克）均使各项血脂指标发生显著变化。硫酸雌酮组和安慰剂组不良事件的发生率相当。每日服用0.625毫克硫酸雌酮联合补充1000毫克元素钙是绝经后女性在12个月期间预防脊柱骨密度流失的最低有效剂量。
