结核分枝杆菌复合群中异烟肼和丙硫异烟胺耐药基因的多态性。
Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex.
机构信息
Molecular Mycobacteriology, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4408-11. doi: 10.1128/AAC.00555-11. Epub 2011 Jun 27.
Abstract
Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.
摘要
对涵盖结核分枝杆菌复合群主要进化谱系的 74 株菌株进行的序列分析显示，mshA（Rv0486）有 10 个多态性，inhA（Rv1484）有 4 个多态性，这些多态性与异烟肼或丙硫异烟胺耐药性无关。相反，这些突变中的一些具有系统发生信息。在开发药物和设计耐药性分子检测时，必须考虑到这种遗传多样性。
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