Institute of Population Genetics, National Research Council of Italy, Sassari, Italy.
Am J Epidemiol. 2011 Aug 15;174(4):432-9. doi: 10.1093/aje/kwr106. Epub 2011 Jun 27.
This study aimed at estimating the prevalence of osteoporosis and osteopenia in a Sardinian isolated population using hand quantitative ultrasound and at investigating the associated factors. The authors utilized a subset of data from a large population-based epidemiologic survey carried out in the Ogliastra region of Sardinia between 2003 and 2008. The sample consists of 6,326 men and women aged ≥30 years, who underwent quantitative ultrasound at the phalanges, bioelectrical impedance, anthropometric measurements, blood tests, and a standardized epidemiologic questionnaire collecting sociodemographic, lifestyle, medical, physiologic, and pharmacologic data. The T-score thresholds for amplitude-dependent speed of sound of -3.2 standard deviations and between -3.2 and -1 standard deviations were used to diagnose osteoporosis and osteopenia, respectively. Prevalence of osteoporosis was 17.0% in women and 5.2% in men. Logistic regression analysis revealed that factors associated with osteoporosis were age, anthropometric and bioimpedance measures, alkaline phosphatase levels, and menopause in women. High education, exercise, and beer consumption seem to be protective factors, whereas a family history of osteoporosis is a risk factor. Results show that osteoporosis in this population is comparable with that found in different countries, suggesting that quantitative ultrasound could be used more widely to detect high-risk individuals for preventing osteoporotic fractures.
本研究旨在使用手部定量超声技术评估撒丁岛一个孤立人群的骨质疏松症和骨量减少症的患病率，并探讨相关因素。作者利用了 2003 年至 2008 年在撒丁岛奥格利亚斯特地区进行的一项大型基于人群的流行病学调查的部分数据。该样本由 6326 名年龄≥30 岁的男性和女性组成，他们在手的指骨处接受了定量超声、生物电阻抗、人体测量、血液检查和标准化的流行病学问卷，以收集社会人口统计学、生活方式、医学、生理学和药理学数据。使用声速衰减标准差-3.2 和-3.2 至-1 标准差的 T 分数阈值分别诊断骨质疏松症和骨量减少症。女性的骨质疏松症患病率为 17.0%，男性为 5.2%。逻辑回归分析显示，与骨质疏松症相关的因素是年龄、人体测量和生物阻抗测量、碱性磷酸酶水平以及女性绝经。高教育程度、运动和啤酒摄入似乎是保护因素，而骨质疏松症家族史是一个风险因素。结果表明，该人群的骨质疏松症与其他国家发现的骨质疏松症相当，这表明定量超声技术可以更广泛地用于检测预防骨质疏松性骨折的高危个体。
