Tetrahydrobiopterin: important endothelial mediator independent of endothelial nitric oxide synthase.
作者信息
Meininger Cynthia J, Wu Guoyao
出版信息
Hypertension. 2011 Aug;58(2):145-7. doi: 10.1161/HYPERTENSIONAHA.111.174003. Epub 2011 Jun 27.
Abstract
摘要
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Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin.过氧化物酶体增殖物激活受体-δ 通过刺激四氢生物蝶呤的生物合成增强人内皮祖细胞的再生能力。
Hypertension. 2011 Aug;58(2):287-94. doi: 10.1161/HYPERTENSIONAHA.111.172189. Epub 2011 Jun 27.
2
GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.GTP 环化水解酶 I/BH4 途径通过抑制氧化应激和血栓素-1 来保护内皮祖细胞，从而预防盐敏感性高血压。
Hypertension. 2010 Dec;56(6):1137-44. doi: 10.1161/HYPERTENSIONAHA.110.160622. Epub 2010 Nov 8.
3
In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I.体内激活AMP活化蛋白激酶可减弱糖尿病增强的GTP环化水解酶I降解。
Diabetes. 2009 Aug;58(8):1893-901. doi: 10.2337/db09-0267. Epub 2009 Jun 15.
4
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.在链脲佐菌素诱导的糖尿病大鼠模型中，HMG-CoA还原酶抑制使内皮型一氧化氮合酶重新偶联的潜在机制。
Atherosclerosis. 2008 May;198(1):65-76. doi: 10.1016/j.atherosclerosis.2007.10.003. Epub 2007 Dec 3.
5
Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells.内皮细胞中四氢生物蝶呤合成与生物利用度的调节
Cell Biochem Biophys. 2004;41(3):415-34. doi: 10.1385/CBB:41:3:415.
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Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats.膳食补充L-精氨酸可增强链脲佐菌素诱导的糖尿病大鼠的内皮一氧化氮合成。
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Tetrahydrobiopterin radical enzymology.四氢生物蝶呤自由基酶学
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Tetrahydrobiopterin levels regulate endothelial cell proliferation.四氢生物蝶呤水平调节内皮细胞增殖。
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