Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2011;47(2):181-91. doi: 10.4415/ANN_11_02_10.
Cancer incidence was investigated in an area which has been affected by the illegal practices of dumping hazardous waste and setting fire to mismanaged waste. For the 35 municipalities of this area that are served by a Cancer Registry, municipal standardized incidence ratios (SIR) and hierarchical Bayesian estimators (BIR) were computed. Moreover, municipal spatial clustering and a Poisson regression by municipality index of waste-related exposure were performed for 10 cancer types. Increased municipality SIRs were found for some cancer types. The BIRs confirmed the increases for liver cancer in two municipalities. Statistically significant clusters were detected for liver, lung, leukaemia and soft tissue sarcomas. In the regression analysis, testis cancer showed significant trend with the index of waste-related exposure (RR = 1.18).
本研究调查了一个曾深受非法倾倒危险废物和随意焚烧垃圾之害地区的癌症发病情况。该地区的 35 个市设有癌症登记处，我们计算了这些市的标准化发病比（SIR）和分层贝叶斯估计（BIR），并对 10 种癌症进行了市间空间聚类和基于市的废物相关暴露指数的泊松回归分析。某些癌症类型的市 SIR 有所增加，BIR 则证实了两个市的肝癌发病率增加。肝、肺、白血病和软组织肉瘤的发病存在统计学显著的聚集性。在回归分析中，与废物相关的暴露指数与睾丸癌呈显著相关（RR=1.18）。
