Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Health Phys. 2011 Aug;101(2):128-35. doi: 10.1097/HP.0b013e318213a5ef.
A molecularly imprinted polymer (MIP) comprising dicyclohexano-18-crown-6 (DCH18C6) was synthesized as a Sr-selective sorbent for urine bioassay purposes. MIP particles (326 ± 2 nm diameter) were formed using acetone and acetonitrile (1:3 v/v) as the porogen, methacrylic acid (MAA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linker. The DCH18C6-MIP particles were impregnated with additional DCH18C6 and treated further with NaOH to attain better binding affinity for Sr(2+). The effects of pH, ionic strength and amount of particles were evaluated for optimal extraction of (90)Sr(2+) from urine samples, as measured by liquid scintillation analysis (LSA). After up to 94% of (90)Y was removed by precipitation with TiO(2), DCH18C6-MIP particles were applied for selective SPE of (90)Sr remaining in the urine matrix for final LSA.
一种包含二环己烷-18-冠-6（DCH18C6）的分子印迹聚合物（MIP）被合成作为尿液生物测定目的的 Sr 选择性吸附剂。MIP 颗粒（直径 326 ± 2nm）是使用丙酮和乙腈（1:3v/v）作为致孔剂、甲基丙烯酸（MAA）作为功能单体和乙二醇二甲基丙烯酸酯（EGDMA）作为交联剂形成的。将 DCH18C6-MIP 颗粒浸渍额外的 DCH18C6 并用 NaOH 进一步处理以获得对 Sr(2+)的更好的结合亲和力。通过液体闪烁分析（LSA）测量，评估了 pH、离子强度和颗粒量对从尿液样品中最佳提取（90）Sr(2+)的影响。在用 TiO(2)沉淀去除高达 94%的（90）Y 后，DCH18C6-MIP 颗粒用于尿液基质中剩余的（90）Sr 的选择性 SPE，用于最终的 LSA。
